Bioengineered implants, magnetic nanoparticles show amazing promise in cancer treatment

By Stephen C. Webster
Sunday, November 29th, 2009 -- 6:11 pm
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cancerribbon  Bioengineered implants, magnetic nanoparticles show amazing promise in cancer treatmentWhat if you could cure cancer by getting a small, circular disk implanted into your arm? Or perhaps instead of undergoing months of soul-wrenching chemotherapy, say one dose of magnetized nanoparticles were able to wipe out your tumors?

That's what scientists are working on and according to two new studies published at the end of November, both methods are showing tremendous promise.

A report published in Sunday's edition of Nature Materials detailed tiny, magnetized "nanodiscs", around 60 billionths of a meter thick, that labratory tests found can be used to disrupt the membranes of cancer cells, causing them to self-destruct.

The discs are made from an iron-nickel alloy, which move when subjected to a magnetic field, damaging the cancer cells, the report said.

One of the study's authors, Elena Rozhlova of Argonne National Laboratory in the United States, said subjecting the discs to a low magnetic field for around ten minutes was enough to destroy 90 percent of cancer cells in tests.

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In a commentary on the report, Jon Dobson of Keele University in Britain said antibodies could be used to direct the discs towards tumor cells.

"This provides an elegant and rapid technique for targeting tumour destruction without the side effects associated with systemic treatments such as chemotherapy," he wrote.

In another study noted by Scientific American, a team of Harvard scientists eradicated cancerous growths in mice by implanting a small, circular disk under the skin.

"Numerous cancer vaccines have shown promise in animal models only to later fail to generate results in humans," noted writer Katherine Harmon. "But an implant-based approach may hold the key, according to a team of immunologists and bioengineers at Harvard University. They designed a tiny polymer disk saturated with dendritic cells and antigens specifically tuned to go after tumor cells."

The tests "[resulted] in complete regression of distant and established melanoma tumors," reads an abstract from the study, published by Science Translational Medicine. The authors said that by triggering the immune system to attack the tumor, "a substantial portion of the population" of cancerous mice saw their lives extended.

Cancer is still the number two killer in the United States behind heart disease, with over 500,000 victims in 2005, according to the Centers for Disease Control.

With AFP.

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Story comments are below...

  • overdoneputaforkinit
    The drug companies will have to work on this to turn it from a cancer cure into a symptom reducer that will keep the patient alive and dependent for years. Otherwise they will lose substantial future profits if left as a cancer cure. Drug companies use patients into dependent producers, like farm animals, that produce income in return for their life (unless they don't have insurance).
  • Schmice
    You are such a cynic, and yet, I see your point and have to agree with you. There is no profit in a cure. Like drug pushers (as it were) they need you to keep coming back.
  • sanchosdad
    there is a cure for cancer that kills tumors by turning apopsitosis (sp?) back on and killing them. its called dichloroacetate. look it up. its been around for 30 years and was already in use for other diseases. no side effects. no LD50 dose. also, no way to patent it. and no money in it.

    it was promptly made illegal for sale in the USA. i wonder why.
  • Schmice
    So where is in use, unless the long arm of the pharmaceutical companies got it baed everywhere.
  • sanchosdad
    you can get it in canada. i got mine from thedcasite.com before it was made illegal.

    http://en.wikipedia.org/wiki/Dichloroacetate
  • Schmice
    Thank you.
  • bajurus
    Be great if one of those would work on prostate cancer since 1 of every six men get hit with that.
  • Schmice
    I hope it works. However, I'm sure Health Insurance Companies will refuse to pay.
  • Elim
    As long as it is experimental, they will refuse to pay, and the cost will be so prohibitive that only the elite will be able to afford it.
  • allenallen
    Nice! Hey, here's an idea... let's spend more money on this shit rather than on blowing up shit! I don't know... just a thought.
  • quizmos
    Yes! But the important question here is: Do these scientists believe in evolution?
  • moxaman
    Well, that's it folks. This will be one of many cancer cures to get shelved. No self respecting pharmacutical company can make a dime from it... so this is the last you'll hear of it.

    Cheers.
  • Elim
    Months ago, I read an article about some researchers using nanoparticles and infrared light to kill cancerous tumors, but the particles had to be injected directly into the tumor. They said they got very good results, equal to or better than what is being reported here. Seems like this is progress compared to the last thing I heard, but that depends on how these nanoparticles get to the tumor. They didn't say, did they?

    You can buy nanoparticles online made from gold, silver, copper or platinum. It is also relatively easy to make your own silver nanoparticles. People drink small amounts of these in water for general health, but I don't see how it would do any good for cancer that way. You can't make your own iron-nickel alloy particles, and I can't even guess how any of them could be magnetized. If a body could figure that out, we the people could take charge of our own cancer cures, completely cutting out big pharma.

    Pharma should make a deal with the tobacco companies. Smokers won't have to quit if they know there is no risk of lung cancer, which will increase tobacco profits. I'm sure pharma lobbyists can come with some kind of sweet deal for them.
  • Phil E. Drifter
    How long until people start thanking 'god' for this, even though god had nothing to do with it and, in fact, worked against it, by creating cancer in the first place?

    /see what I'm getting at here?
    /there is no god
    ///get over it
    ////what a stupid concept, that we're somehow special and have a place to go after we die
  • OldAtlantic
    Stopping illegal cancer is a good beginning.
  • dennycrane
    Like quit putting depleted uranium on weapons in iraq/afghanistan so the soldiers come back all fucked up and then get denied medical coverage for their cancers, plus making a "toxic" dump out of sovereign countries. Oh yeah, I forgot, that is the plan of the christers.
  • farang
    Why are we wasting money on research like this when we have WARS to fund??? Occupations and invasions to conduct?

    Killer drones to build, foreign governments to loan to, Single Payer insurance to avoid........
  • howiebledsoe
    Oh, shit. A cure for cancer. Did you know that more money is made annually on cancer research alone than cancer treatment in hospitals? It´s true. Cancer is a HUGE industry. Chemotherapy is an outdated idea from the 50´s, and so out dated it hurts, no pun intended. This will either get shelved, or the cure will be so expensive to be out of reach for ordinary citizens who will soon become too 3rd world to afford any kind of health care anyway.
  • erico
    This is exciting! Too bad it will never see the light of day as long as PhRMA has Congress in it's back pocket!
  • mmeflutterbye
    This is the kind of thing our government should be spending our tax dollars on...not killing people in an unending war.
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